Critical Process Filtration Blog

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Bacteria Reduction/Removal | Pharmaceutical Filtration | Biopharmaceutical Filtration | Filters in Water Treatment Systems | Tank Vent Filters | Food & Beverage Filtration

By: Critical Process Filtration
September 27th, 2022

   Most Commonly Asked Filtration Question Series     The risks of not using vent filters on holding and mixing tanks are real and costly. Unfortunately, we usually hear from a company after they've experienced serious issues because they did not install vent filters. So, this article is written for those not yet using vent filters on their tanks. It will address the most common issues/questions we're asked on this topic with the hope of sparing you a process headache you don't need. Many processes require the use of tanks for holding ingredients to be added into the process, mixing of ingredients, or to hold the final product pending final filtration and filling. During the course of normal operations these tanks will be filled and emptied many times.

Blog Feature

Pharmaceutical Filtration | Biopharmaceutical Filtration | Filters in Water Treatment Systems | Pharmaceutical Water | Food & Beverage Filtration

Extractables and Leachables, these terms are a part of the manufacturing process of new medicines and other areas of such. These terms are very commonly misunderstood by one another and they both gave their distinct characteristics, which can be traced through the whole supply chain.  The definitions of these are not balanced. They overlap and have different utilization, and situations in the manufacturing process must be categorized to highlight the weight and necessity of both extractables and leachables.

Blog Feature

Filter System Design | How-To | Problem Solving

DEVELOPMENT, SCALE-UP, AND VALIDATION OF PHARMACEUTICAL FILTRATION PROCESSES Our Technical Service Team performs application testing for a wide variety of fluids from water to complex chemical solutions. No matter what industry the customer is part of, we carefully document our test results and make recommendations based on those results. We get it right the first time.  For pharmaceutical applications, whether removing particles from ingredients entering the plant or sterilizing parenteral products, the testing and documentation we routinely create help show the consistent performance required for validation of the process.

Blog Feature

Particle Filtration | Nominal vs Absolute Filters

While filter ratings are an important indication of how well the filter will remove particles of varying sizes from a fluid or gas, it is important to note that nominally rated filters from different manufacturers can have the same rating, but yield different results. The opposite is also true – nominally rated filters from different suppliers can have different ratings, yet yield the same result. Naturally, this can create confusion and impact your filter buying decisions. When these situations arise, we recommend that focusing on achieving the targeted performance of a filter over the rating will yield the best results. With that in mind, let’s start with differentiating between the two types of ratings that indicate pore size and efficiency in removing particulates -- Nominal and Absolute ratings.

Blog Feature

How-To | Integrity Testing | Pressure Decay Test

By: Critical Process Filtration
May 12th, 2022

A simpler integrity test for less critical applications is a Pressure Decay Test. This requires the same air (or nitrogen) source and an accurate pressure gauge but does not require a mass flow meter. This type of test can be performed before and after use and is sensitive enough to detect very small leaks.

Blog Feature

Sterilizing Filtration | Endotoxin Removal | Bioprocessing | Biotechnology Filtration | Filter Equivalents

By: Critical Process Filtration
March 10th, 2022

Your process requires a sterile end product. To achieve this, you plan on installing a sterilizing filter. But with so many choices, how do you choose the best one? Some suppliers offer single layer membrane sterilizing filters. Others may offer filters with two layers of membrane, sometimes with different pore sizes (a larger pore size in front of the final sterilizing filter), or two layers of the identical material in the same pore size. Each plays a specific role in reaching your sterilizing requirements. This article will discuss the many factors in choosing a sterilizing filter and list our products that deliver targeted retention.

Blog Feature

Filter System Design | Problem Solving

By: Critical Process Filtration
February 17th, 2022

One of the first questions many customers ask when evaluating filtration solutions is, “how many filters will I need?” Getting to the correct answer requires consideration of many factors.

Blog Feature

Sterilizing Filtration | Pharmaceutical Filtration | Biopharmaceutical Filtration | Pharmaceutical Water | Improve Filter Performance | Bioprocessing | Biotechnology Filtration | Filter Equivalents

By: Critical Process Filtration
January 4th, 2022

How to evaluate a replacement filter equivalent to the one you're using now. For any number of reasons, you’re looking for a new filter supplier. If your current filtration performance is satisfactory, replacing the filters with the correct equivalent will do. But if you need to improve filter performance, a different configuration of your current filter or a different type of filter will be the solution. Either way, a quality supplier should take the time to determine exactly what equivalent means to you, and help you identify the appropriate filter(s).

Blog Feature

Problem Solving | Filter Ratings | Nominal vs Absolute Filters

By: Critical Process Filtration
December 6th, 2021

Pore size ratings are an important indicator of how well a filter will remove particles of varying sizes from a liquid or gas. It is just as important to take into consideration whether the filter rating is Absolute or Nominal, and the removal efficiency stated for the rated pore size, as not all nominal rated filters are created equal.