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How-To | Integrity Testing | Pressure Decay Test

By: Critical Process Filtration
May 12th, 2022

A simpler integrity test for less critical applications is a Pressure Decay Test. This requires the same air (or nitrogen) source and an accurate pressure gauge but does not require a mass flow meter. This type of test can be performed before and after use and is sensitive enough to detect very small leaks.

Blog Feature

Sterilizing Filtration | Endotoxin Removal | Bioprocessing | Biotechnology Filtration | Filter Equivalents

By: Critical Process Filtration
March 10th, 2022

Your process requires a sterile end product. To achieve this, you plan on installing a sterilizing filter. But with so many choices, how do you choose the best one? Some suppliers offer single layer membrane sterilizing filters. Others may offer filters with two layers of membrane, sometimes with different pore sizes (a larger pore size in front of the final sterilizing filter), or two layers of the identical material in the same pore size. Each plays a specific role in reaching your sterilizing requirements. This article will discuss the many factors in choosing a sterilizing filter and list our products that deliver targeted retention.

Blog Feature

Filter System Design | Problem Solving

By: Critical Process Filtration
February 17th, 2022

One of the first questions many customers ask when evaluating filtration solutions is, “how many filters will I need?” Getting to the correct answer requires consideration of many factors.

Blog Feature

Sterilizing Filtration | Pharmaceutical Filtration | Biopharmaceutical Filtration | Pharmaceutical Water | Improve Filter Performance | Bioprocessing | Biotechnology Filtration | Filter Equivalents

By: Critical Process Filtration
January 4th, 2022

How to evaluate a replacement filter equivalent to the one you're using now. For any number of reasons, you’re looking for a new filter supplier. If your current filtration performance is satisfactory, replacing the filters with the correct equivalent will do. But if you need to improve filter performance, a different configuration of your current filter or a different type of filter will be the solution. Either way, a quality supplier should take the time to determine exactly what equivalent means to you, and help you identify the appropriate filter(s).

Blog Feature

Problem Solving | Filter Ratings | Nominal vs Absolute Filters

By: Critical Process Filtration
December 6th, 2021

Pore size ratings are an important indicator of how well a filter will remove particles of varying sizes from a liquid or gas. It is just as important to take into consideration whether the filter rating is Absolute or Nominal, and the removal efficiency stated for the rated pore size, as not all nominal rated filters are created equal.

Blog Feature

Problem Solving | Filtration Troubleshooting

By: Critical Process Filtration
January 7th, 2021

When a process does not perform as expected, asking the question “what changed” is the best place to start. For over 20 years we have been helping customers find the culprit in their filtration process when suddenly results go awry. A robust, professionally designed filtration system will work the same way, every day, until something changes. Intentional changes are easy to figure out, but what happens when something changes in the process and no one is aware until a batch is compromised? That’s a critical point for process review and troubleshooting. Here are the top questions we ask in determining "what changed" so we can help get your operation back on track.

Blog Feature

Bacteria Reduction/Removal | Pharmaceutical Filtration | Biopharmaceutical Filtration | Filters in Water Treatment Systems | Endotoxin Removal | Bioprocessing

By: Critical Process Filtration
December 8th, 2020

   Most Commonly Asked Filtration Question Series   You’ve sanitized your system. You have sterilizing grade filters installed at key points in your process. Your bioburden measurements are low but you still have endotoxin issues. What’s going on?

Blog Feature

Bacteria Reduction/Removal | Integrity Testing | Water Intrusion Integrity Test | Diffusion Integrity Test

By: Critical Process Filtration
December 2nd, 2020

If you’re using filtration to remove bacteria from your process, integrity testing will provide you with data to ensure product quality. Did you know you can perform integrity testing in-house without the huge expense of buying commercial equipment?

Blog Feature

Bacteria Reduction/Removal | Pharmaceutical Filtration | Biopharmaceutical Filtration | Filters in Water Treatment Systems | Tank Vent Filters | Food & Beverage Filtration

By: Critical Process Filtration
July 7th, 2020

   Most Commonly Asked Filtration Question Series     The risks of not using vent filters on holding and mixing tanks are real. And costly. Unfortunately, we usually hear from a company after they've experienced serious issues because they did not install vent filters. So, this article is written for those not yet using vent filters on their tanks. It will address the most common issues/questions we're asked on this topic with the hope of sparing you a process headache you don't need. Many processes require the use of tanks for holding ingredients to be added into the process, mixing of ingredients, or to hold the final product pending final filtration and filling. During the course of normal operations these tanks will be filled and emptied many times.