Most Commonly Asked Filtration Question Series The risks of not using vent filters on holding and mixing tanks are real and costly. Unfortunately, we usually hear from a company after they've experienced serious issues because they did not install vent filters. So, this article is written for those not yet using vent filters on their tanks. It will address the most common issues/questions we're asked on this topic with the hope of sparing you a process headache you don't need. Many processes require the use of tanks for holding ingredients to be added into the process, mixing of ingredients, or to hold the final product pending final filtration and filling. During the course of normal operations these tanks will be filled and emptied many times.
A simpler integrity test for less critical applications is a Pressure Decay Test. This requires the same air (or nitrogen) source and an accurate pressure gauge but does not require a mass flow meter. This type of test can be performed before and after use and is sensitive enough to detect very small leaks.
Your process requires a sterile end product. To achieve this, you plan on installing a sterilizing filter. But with so many choices, how do you choose the best one? Some suppliers offer single layer membrane sterilizing filters. Others may offer filters with two layers of membrane, sometimes with different pore sizes (a larger pore size in front of the final sterilizing filter), or two layers of the identical material in the same pore size. Each plays a specific role in reaching your sterilizing requirements. This article will discuss the many factors in choosing a sterilizing filter and list our products that deliver targeted retention.
How to evaluate a replacement filter equivalent to the one you're using now. For any number of reasons, you’re looking for a new filter supplier. If your current filtration performance is satisfactory, replacing the filters with the correct equivalent will do. But if you need to improve filter performance, a different configuration of your current filter or a different type of filter will be the solution. Either way, a quality supplier should take the time to determine exactly what equivalent means to you, and help you identify the appropriate filter(s).
Pore size ratings are an important indicator of how well a filter will remove particles of varying sizes from a liquid or gas. It is just as important to take into consideration whether the filter rating is Absolute or Nominal, and the removal efficiency stated for the rated pore size, as not all nominal rated filters are created equal.
When a process does not perform as expected, asking the question “what changed” is the best place to start. For over 20 years we have been helping customers find the culprit in their filtration process when suddenly results go awry. A robust, professionally designed filtration system will work the same way, every day, until something changes. Intentional changes are easy to figure out, but what happens when something changes in the process and no one is aware until a batch is compromised? That’s a critical point for process review and troubleshooting. Here are the top questions we ask in determining "what changed" so we can help get your operation back on track.
If you’re using filtration to remove bacteria from your process, integrity testing will provide you with data to ensure product quality. Did you know you can perform integrity testing in-house without the huge expense of buying commercial equipment?
Most Commonly Asked Filtration Question Series Integrity Testing is a requirement of suppliers selling absolute rated membrane cartridge filters for microbial reduction or removal of yeast and mold. Test results are validated to remove specific organisms and a certificate is included with each product proving the quality of the filter. In addition to vendor testing, manufacturers in different industries perform their own Integrity Tests for critical processes. In pharmaceutical and bioprocessing, industry regulations call for Integrity Testing at prescribed intervals in a process. In the Food & Beverage industry, although not mandatory, Integrity Testing is a strategic move in assuring product safety and quality. Today we'll discuss the need and steps for in-process integrity testing.